Pilot Scale Bioreactors

Working volume from 10 - 15 000 Liters.

MAGNETIC
DRIVE

Novel magnetic coupling agitator – top or bottom mounted.

AERATION

Aeration through ring sparger with aeration rate up to 2 vvm.

TECHNOLOGICAL
SKID

Sensors and valves ensure fully automated process control.

STAINLESS-STEEL
VESSEL

Vessel produced from certified surgical steel 316L

MADE IN
EUROPE

Manufactured adhering to the highest standards of quality and innovation

Pilot Scale Bioreactors

The Pilot scale series, in standard configuration, SIP fermenters/bioreactors are available in a wide range of working volumes from 10 – 15000 L liters, with multiple variations and customization options. Choose one of the Standard versions of Pilot Scale fermenters/bioreactors or customize Your own using the configurator. All pilot bioreactors are fully custom made to meet your specific needs.

Our configurator makes it easy to prepare a request and add additional features:

The models with working volume from 10 to 350 L are the perfect choice for scaling up bioprocesses from Lab scale and for initiating a small scale production before industrial scale-up. For larger volume fermenters/bioreactors use our configurator to specify reactor design or send Your request via email with Technical Specification and requirements.

All stainless-steel bioreactors with working volume from 10 – 15000 L are autonomous and consist of three main parts:

Technological skid and fermenter/bioreactor vessel can be interconnected with Corrugated PTFE hoses reinforced with single stainless steel (AISI 304) braid or could be integrated within a single frame.

Summary

Vessel design

Fermenter/Bioreactor vessel has an insulated jacket. (Insulation – mineral wool) thickness varies from 50 to 100 mm. Insulation is plated with Stainless steel (AISI 304). Vessel can be equipped with flat or torispherically flanged, moveable lid (till 800 L). Larger vessels are equipped with a manhole of corresponding size to ensure serviceability and maintenance.

Mixing

Novel magnetic coupling agitator – top or bottom mounted. For microbial cultures 2-3 Rushton turbines are used to mix the media. Optionally pitched blade or marine impellers are available for shear sensitive conditions.

Agitator speed range for various working volume fermenters/reactors:

10 to 50 L: 750 rpm

70 to 150 L: 650 rpm

200 to 300 L: 600 rpm

400 to 650 L: 450 rpm

700 to 1000 L: 320 rpm

2500 L: 200 rpm

4000 L: 180 rpm

10000 L: 120 rpm

15000 L: 100 rpm

Aeration

Aeration through ring sparger with aeration rate up to 2 vvm.

Optionally air supply overlay, mass flow controllers (MFC), addition up to four different gases: (Oxygen, Nitrogen, Carbon Dioxide).

Aeration system includes:

Control cabinet

Stainless steel control cabinet (Rittal, Germany) with built-in Siemens PLC and Weintek touch panel. Profinet connection to LAN or WAN

Automatic process control is ensured by the following sensors:

*Stainless steel control cabinet (Rittal, Germany) with built-in Siemens PLC and Weintek touch panel. Profinet connection to LAN or WAN

In customized versions several optional sensors are available:

Technical Specification describes Pilot Scale fermenters/bioreactors with working volume from 10 – 350 liters in Standard configurations. For customization or different configuration purposes use our configurator to prepare Your request.

Technological skid

Technological skid – system of pipes, valves and sensors which ensure supply of technological medias to the vessel – air, steam, clean steam, water as well as cooling water and condensate return from the system. Sensors and valves ensure fully automated process control.

Several processes can be performed in automatic mode:

To See our standard options click here: